Johanna A Joyce Selected Research

Cysteine (L-Cysteine)

1/2016	Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.
1/2016	STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.
1/2016	Microenvironmental InterFereNce of metabolism regulates chemosensitivity.
12/2015	Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response.
8/2015	Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells.
1/2015	Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
11/2010	Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model.
8/2010	Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer.
8/2008	Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth.
1/2008	Cysteine cathepsin proteases as pharmacological targets in cancer.

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Johanna A Joyce Research Topics

Disease

48	Neoplasms (Cancer) 10/2021 - 11/2003
12	Neoplasm Metastasis (Metastasis) 10/2021 - 02/2010
10	Carcinogenesis 01/2016 - 11/2003
9	Breast Neoplasms (Breast Cancer) 01/2019 - 02/2010
3	Glioma (Gliomas) 01/2020 - 10/2013
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2016 - 11/2010
2	Glioblastoma (Glioblastoma Multiforme) 07/2022 - 01/2020
2	Hypoxia (Hypoxemia) 01/2019 - 01/2017
2	Atherosclerosis 11/2017 - 01/2016
2	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2016 - 10/2014
2	Inflammation (Inflammations) 01/2016 - 08/2008
2	Necrosis 01/2016 - 03/2013
1	Brain Neoplasms (Brain Tumor) 01/2019
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 11/2017
1	Liver Diseases (Liver Disease) 11/2017
1	Nervous System Diseases (Neurological Disorders) 11/2017
1	Weight Loss (Weight Reduction) 08/2017
1	Obesity 08/2017
1	Pain (Aches) 01/2016
1	Metaplasia 01/2016
1	Stroke (Strokes) 01/2016
1	Ovarian Neoplasms (Ovarian Cancer) 01/2016
1	Chronic Pancreatitis 01/2016
1	Pancreatitis 01/2016
1	Histiocytic Sarcoma 01/2016
1	Primitive Neuroectodermal Tumors (PNET) 01/2015
1	Melanoma (Melanoma, Malignant) 07/2014
1	Bites and Stings (Sting) 04/2014
1	Vaccinia 04/2014
1	Infections 04/2014

Drug/Important Bio-Agent (IBA)

19	CathepsinsIBA 01/2016 - 05/2004
17	Peptide Hydrolases (Proteases)FDA Link 01/2016 - 05/2004
15	Cysteine (L-Cysteine)FDA Link 01/2016 - 05/2004
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2004
5	Pharmaceutical PreparationsIBA 11/2017 - 01/2007
5	Cathepsin BIBA 11/2017 - 03/2006
5	EnzymesIBA 01/2016 - 03/2006
5	Cysteine Proteases (Cysteine Protease)IBA 01/2016 - 05/2004
4	CytokinesIBA 01/2016 - 12/2010
3	Lactic Acid (Lactate)FDA LinkGeneric 01/2019 - 11/2013
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2016
3	Phosphotransferases (Kinase)IBA 11/2014 - 04/2011
3	PapainIBA 11/2010 - 05/2007
2	Macrophage Colony-Stimulating FactorIBA 10/2021 - 01/2019
2	Biological ProductsIBA 10/2020 - 08/2008
2	IronIBA 01/2019 - 01/2017
2	HemosiderinIBA 01/2019 - 01/2017
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 08/2017 - 10/2013
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2017 - 12/2011
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2015 - 06/2005
2	cathepsin SIBA 08/2015 - 09/2014
2	Messenger RNA (mRNA)IBA 01/2015 - 06/2005
2	DNA (Deoxyribonucleic Acid)IBA 04/2014 - 01/2013
2	Cathepsin CIBA 03/2013 - 03/2006
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/2011 - 08/2007
2	ChemokinesIBA 04/2011 - 08/2010
2	Interleukin-4 (Interleukin 4)IBA 12/2010 - 02/2010
2	Cadherins (E-Cadherin)IBA 01/2007 - 03/2006
1	4- (2- (2- hydroxycyclohexylamino)benzothiazol- 6- yloxy)pyridine- 2- carboxylic acid methylamideIBA 10/2021
1	Choline (Choline Chloride)IBA 01/2019
1	N-acetylaspartate (N-acetyl aspartate)IBA 01/2019
1	CreatineIBA 01/2019
1	Contrast MediaIBA 01/2019
1	A 7 (A-7)IBA 01/2019
1	LipidsIBA 11/2017
1	Interleukin-5 (Interleukin 5)IBA 08/2017
1	Mannose ReceptorIBA 01/2017
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2017
1	ArginaseIBA 01/2017
1	ChromatinIBA 11/2016
1	IGF Type 1 Receptor (IGF 1 Receptor)IBA 05/2016
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 05/2016
1	Insulin (Novolin)FDA Link 05/2016
1	CeruletideIBA 01/2016
1	asparaginylendopeptidase (legumain)IBA 01/2016
1	Methotrexate (Mexate)FDA LinkGeneric 01/2016
1	Cisplatin (Platino)FDA LinkGeneric 01/2016
1	Glutathione (Reduced Glutathione)IBA 01/2016
1	AminesIBA 01/2016
1	Membrane Proteins (Integral Membrane Proteins)IBA 08/2015
1	ras ProteinsIBA 08/2015
1	Extracellular Matrix ProteinsIBA 08/2015
1	Cathepsin LIBA 01/2015
1	Cell Adhesion MoleculesIBA 11/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2014
1	arginyl-glycyl-aspartic acidIBA 10/2014
1	Cathepsin ZIBA 10/2014
1	IntegrinsIBA 10/2014
1	Monomeric GTP-Binding ProteinsIBA 07/2014
1	Interferon Type IIBA 04/2014
1	Virulence Factors (Pathogenicity Factors)IBA 04/2014
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 04/2014
1	VaccinesIBA 04/2014
1	chenodeoxycholate sulfate conjugate (CDCS)IBA 04/2014
1	Mechanistic Target of Rapamycin Complex 1IBA 12/2013

Therapy/Procedure

11	Therapeutics 07/2022 - 12/2006
5	Drug Therapy (Chemotherapy) 01/2019 - 08/2007
2	Radiotherapy 01/2020 - 01/2019
2	Immunotherapy 01/2019 - 04/2015
1	Transplantation 05/2016